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Eating junk food can trigger aches or make people more sensitive to pain — even if they are healthy and slim, a study suggests.

Certain fats in fast food can cause cholesterol to build up in the arteries leading to inflammation, which leads to joint ache and makes people more sensitive to pain.

It is well documented that being obese or eating junk over a long time can lead to chronic pain, but now researchers say even just a few off meals may cause damage.

A study of mice found saturated fat in the blood binds to nerve cell receptors that leads to inflammation and mimics the symptoms of nerve damage.

The process was observed after just eight weeks on a high fat diet which did not have enough calories to make the rodents overweight. 

Dr Michael Burton, assistant professor of neuroscience at UT Dallas, said: 'This study indicates you don’t need diabetes; you don't need need a pathology or injury at all.

'Eating a high-fat diet for a short period of time is enough — a diet similar to what almost all of us in the U.S. eat at some point.'

Previous studies have looked at the relationship of high fat diets with mice who also were obese or had diabetes.

It comes after a study found intermittent fasting – one of the most popular and promoted dieting techniques – may actually raise the risk of an early death.

Eating junk food can trigger chronic pain — even in healthy and slim people, a study suggests (file image) 

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'But this recent study took out further variables and was able to start identifying the direct connection of diet on chronic pain,' Laura Simmons, a dietitian who was not involved in the study, told Medical News Today.

The research, published in the journal Scientific Reports, compared the effects of different diets on two sets of mice over eight weeks. 

One received normal food, while the other was fed a high-fat diet that would not cause obesity. 

The researchers looked for saturated fats in their blood. They found mice on the high-fat diet had higher levels of palmitic acid.

They also observed the fat binding to the nerve receptor TLR4, causing it to release inflammatory markers.

The researchers believe drugs that target that receptor could be key to preventing inflammation and pain caused by bad diets. 

Dr Burton added: 'Now that we see that it’s the sensory neurons that are affected, how is it happening? 

'We discovered that if you take away the receptor that the palmitic acid binds to, you don’t see that sensitizing effect on those neurons. 

'That suggests there’s a way to block it pharmacologically.'

Dr Burton wants doctors to probe whether a bad diet could be behind patient's pain, even if they are not obese and seem otherwise healthy.


• Eat at least 5 portions of a variety of fruit and vegetables every day. All fresh, frozen, dried and canned fruit and vegetables count

• Base meals on potatoes, bread, rice, pasta or other starchy carbohydrates, ideally wholegrain

• 30 grams of fibre a day: This is the same as eating all of the following: 5 portions of fruit and vegetables, 2 whole-wheat cereal biscuits, 2 thick slices of wholemeal bread and large baked potato with the skin on

• Have some dairy or dairy alternatives (such as soya drinks) choosing lower fat and lower sugar options

• Eat some beans, pulses, fish, eggs, meat and other proteins (including 2 portions of fish every week, one of which should be oily)

• Choose unsaturated oils and spreads and consuming in small amounts

• Drink 6-8 cups/glasses of water a day

• Adults should have less than 6g of salt and 20g of saturated fat for women or 30g for men a day

Source: NHS Eatwell Guide 

Read more:
  • High fat diets may contribute to chronic pain, study shows
  • High-fat diet causes mechanical allodynia in the absence of injury or diabetic pathology | Scientific Reports

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Tags: topics index fruit and vegetables you don’t inflammation a study suggests even if they a high fat diet the researchers to inflammation to chronic pain high fat diet fast food can saturated fat eating junk portions eight weeks

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WATCH: High school football team wins championship with wild last-second touchdown

The final play of a Minnesota high school football championship was an answered prayer as a hail mary led New London-Spicer High School to victory in the waning seconds of the game.

Quarterback Blake Schultz threw the ball from near midfield approximately 35 yards to wide receiver Grant Paffrath, who then lateraled the ball to wide receiver Brycen Christensen, who ran into the end zone for the game-winning touchdown, beating Dilworth-Glyndon-Felton Senior High School 27-26.


Minneapolis Miracle: Part 2.

Incredible finish at the Prep Bowl on @kstc45 as @NLS_Wildcat_AD scores the game-winning touchdown as the clock hits zero in the Class 3A championship game.#SCTop10

— James Monical (@jwmonicalKSTP) December 3, 2022

The clutch game-winning play made the Top 10 list on ESPN's SportsCenter on Saturday, landing at the top position for the best plays in all of sports for the day, according to the "worldwide leader in sports."


Saturday's Class 3A state championship is the second for New London-Spicer, with its other state football championship coming in 2009.

The game was held at U.S. Bank Stadium in Minneapolis, Minnesota, where the Minnesota Vikings clinched a victory in the NFL playoffs via the Minneapolis miracle nearly five years ago.

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