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Comedian and podcaster Joe Rogan has chimed in on the highly-publicized court case between actors and former spouses Johnny Depp and Amber Heard, claiming the latter is 'full of s**t'.

Depp is suing Heard for $50 million plus legal fees on grounds of defamation, arguing that claims of abuse she made in a 2018 essay published in The Washington Post were false and derailed his career.

The Pirates of the Caribbean star also alleges that he was the victim of abuse at the hands of Heard, who maintains she told the truth in her article and is counter-suing for $100 million.

On Joe's Tuesday podcast with fellow comedian Jessica Kirson, the pair opened the show by discussing the trial, with Joe tearing into 'crazy' Heard.

'That's what happens with people like that. People that are just manipulative and full of s**t like that,' he said.

'[Comedian Doug Stanhope] knows her. Stanhope's buddies with Johnny Depp. He wrote something, like an essay about how full of s**t she is, and she threatened to sue him, and I think he had to wind up taking it down.

'He knows her well... He's like, ''She's out of her f**king mind like a crazy actress!' 

Joe made reference to Heard's claims she used a specific make-up kit produced by cosmetic brand Milani to cover up bruises allegedly inflicted by Depp in 2016.

The brand refuted her claims, pointing out the make-up kit in question was not released until after the pair had divorced in 2017.

In the latest from the Depp-Heard trial: 

  • Johnny Depp's former agent Christian Carino told the court about emails sent to him by Heard after she broke up with Elon Musk
  • Heard began dating the Tesla founder around the time of her split with Depp
  • Heard told Carino: 'I hate when things go public. See I'm so sad.'  
  • 'Yet again a man lets me fall on the spikes by myself,' Heard's email read
  • Carino retorted: 'You could avoid all this if you stop dating uber famous people'
  • Meanwhile, Depp's doorman Alejandro Romero gave a 'bizarre' deposition 
  • Depp cracked up with laughter as Romero described how Heard asked him to investigate an intruder due to scratches on their front door - caused by the dog
  • Heard is expected to take the stand for her highly-anticipated testimony in days 

On Joe's Tuesday podcast with fellow comedian Jessica Kirson, the pair opened the show by discussing the trial, with Joe tearing into 'crazy' Heard

Actor Amber Heard leaves the courtroom at the Fairfax County Circuit Court in Fairfax, Va., Wednesday, April 27, 2022

Actor Johnny Depp gestures as he stands in the courtroom during a recess amid his defamation trial against his ex-wife Amber Heard, at the Fairfax County Circuit Courthouse in Fairfax, Virginia, on April 27, 2022

In the first seconds of the Tuesday episode of The Joe Rogan Experience, Joe said: 'I'm watching this trial, and, like, it's a cautionary tale about believing in bulls**t, forming a narrative in your head.

'That's what I felt like about Anthony Bourdain and his relationship to that crazy woman,' he said, referencing the late chef and travel documentarian's tumultuous relationship with Italian film star Asia Argento. 

'You're seeing all the crazy come out,' he concluded.

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Yesterday, Depp's former agent Christian Carino told the court about emails sent to him by Heard after she broke up with Elon Musk.

Heard began dating the Tesla founder around the time of her split with Depp in May 2016 and by August the following year they had broken up.

Carino, a talent agent with mega agency CAA and Lady Gaga's ex-fiance, appeared by a pre-recorded video deposition and confirmed that Heard and Musk were in a relationship for a time.

Asked if Heard moved on to dating Musk 'immediately after Johnny Depp', Carino said yes.

In an email on August 7, 2017, Heard told Carino: 'Dealing with breakup. I hate when things go public. See I'm so sad,' in reference to her split with Musk.

Carino replied to Heard: 'You weren't in love with him. You told me 1,000 times you were just feeling space.'

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Only Lyme disease vaccine in development goes to Phase 3 trial

(CNN)Vaccine maker Pfizer says it has begun Phase 3 clinical trial of its vaccine candidate against Lyme disease with French vaccine company Valneva SE.

The biotech companies are recruiting about 6,000 participants age 5 and older at up to 50 sites in areas of Europe and the US where Lyme disease is endemic, they said Monday in a news release.The participants will get three doses of the vaccine, called VLA15, or a placebo, followed by a booster dose.
    "With increasing global rates of Lyme disease, providing a new option for people to help protect themselves from the disease is more important than ever," Annaliesa Anderson, senior vice president and head of vaccine research and development at Pfizer, said in the news release.
      VLA15 is the only Lyme vaccine in clinical development, Pfizer said in the statement. It targets the bacteria Borrelia burdorferi, the main cause of the tick-borne disease, and has "demonstrated a strong immune response and satisfactory safety profile in pre-clinical and clinical studies so far."Read MoreIf the trial shows that the vaccine is safe and effective, Pfizer says, it could submit requests for approval from the US Food and Drug Administration and the European Medicines Agency in 2025.What is Lyme disease?
        Lyme disease is the most common vector-borne disease in the US, according to the US Centers for Disease Control and Prevention, and it's becoming common in more areas. CDC: Lyme disease more common than we thoughtAn estimated 476,000 Americans are diagnosed and treated for Lyme disease each year, although the CDC says this is probably an overcount because people are sometimes treated without official confirmation that they have the disease. The only vaccine previously marketed in the US was discontinued in 2002.Lyme disease symptomsFever, chills, body aches, swollen lymph nodes, neck stiffness, shortness of breath, headache, fatigue and a rash are all typical symptoms of Lyme disease.When you get bit by a tick, you will typically see a small red bump that may look like a mosquito bite. But three to 30 days later, if a rash shows up and expands from that red area and looks a little like a bull's-eye, that's a sign you may have Lyme disease.Justin Bieber reveals hes battling Lyme diseaseDoctors will call this rash erythema migrans. Often, it will expand slowly. It's not normally itchy or painful, but the area may feel a little warm when you touch it.Between 70% and 80% of people with Lyme disease develop this rash, and some get it at more than one place on their bodies.Left untreated, the infection can spread to the joints, heart and nervous system, according to the CDC. This can lead to joint pain and swelling.After several weeks to months, there may also be swelling of the membranes surrounding the brain, temporary paralysis of one side of the face and "brain fog": forgetfulness or confusion.How people get Lyme diseaseLyme disease comes from four main species of bacteria. In the US, it's Borrelia burgdorferi; on occasion, Borrelia mayonii can also cause the disease, according to the CDC.An infected tick transfers the bacteria when it bites. There are several kinds of ticks in the US that carry the bacteria that causes Lyme disease, and with warming temperatures, they can be found in nearly every county. Amy Schumer reveals she has Lyme disease Most commonly, blacklegged ticks, also known as deer ticks, carry Lyme disease. They live in the northeastern US, Midatlantic and upper Midwest. The Lyme disease-carrying Western blacklegged tick can be found along the Pacific coast.Most people get sick with Lyme disease in the spring and summer months. That's when the immature ticks called nymphs are most actively feeding, and that's when most people are out and about, walking through grass and the heavily wooded areas where the bugs like to hang out.What to do if you get bittenTicks can be tiny: Deer ticks may be as small as the head of a pin, so look for them carefully.Removing a tick within 24 hours cuts your risk of developing Lyme disease. The longer the tick is attached to the body, the more likely that person will be infected. Use tweezers to carefully and steadily pull the tick off, grasping near its mouth or neck. Then put antiseptic on the infected area.It typically takes about 36 to 48 hours for the bacterium to move from the tick to the person it is attached to, according to the CDC.If you've been bitten and develop symptoms, call your doctor immediately. Even if your symptoms disappear, you should still see a doctor.Lyme diseae treatmentThe standard treatment for Lyme disease in early stages is oral antibiotics. Usually, a 14- to 21-day course is recommended, but some studies suggest that a 10- to 14-day course is equally effective, according to the Mayo Clinic.Warmer weather means its time to be tick awareIf the central nervous system has been affected by the disease, intravenous antibiotics may be given for 14 to 28 days. This treatment eliminates the infection, but you may need more time to recover from symptoms. The side effects from this treatment may include a lower white blood cell count, diarrhea or infection with other organisms resistant to antibiotics that are unrelated to Lyme disease.People who are put on antibiotics early in the disease generally make a full recovery, according to the Mayo Clinic. It may take patients who get treated later in the infection longer to respond to treatment.Most people, regardless of when they get help, recover completely, but about 5% to 20% have persistent symptoms, and some can be disabling.PreventionThe CDC recommends wearing insect repellent with at least a 20% DEET concentration and avoiding wooded areas with high grass, where ticks are most often found.Check for ticks daily and, if you spend a lot of time outdoors, take frequent showers. A washcloth can help remove unattached ticks.Tick season is here. Heres what you need to knowWhen you are outside, cover up. Wear long sleeves, long pants and hats when walking or hiking in the woods.Your dogs and cats can also bring the pests inside, so check them and tick-proof your yard. Clear out the leaves and brush where ticks like to hide. Keep your lawn mowed.More facts about ticksThese arachnids can't fly or jump but rather wait for a host -- whether it be a mammal, bird, reptile or amphibian -- to feed on while resting on the tips of grasses and shrubs. They hold on to leaves and grass with their lower legs, a position called "questing."Get CNN Healths weekly newsletter

        Sign up here to get The Results Are In with Dr. Sanjay Gupta every Tuesday from the CNN Health team.

          As the host passes by, the tick climbs on and finds a place to bite.Besides Lyme disease, at least 20 known medical conditions can result from tick bites.

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